Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases.

ABSTRACT:

Background

macrophage-targeting therapy of ischemic disease has made progress in clinic trial. However, the role and underlying mechanism of pro-inflammatory or anti-inflammatory polarized macrophages in modulating ischemic diseases remain incompletely understood.

Results

here we examine the effect of pro-inflammatory (LPS) and anti-inflammatory (IL-4) macrophage on ischemic diseases in a mouse ischemic hindlimb and heart model, and identify that signal regulatory protein α (Sirpα) modulates macrophage polarization induced angiogenesis via promoting phagocytosis or activating HIF1α nucleus relocation in macrophages, respectively. More importantly, the therapeutic effect of polarized macrophages is controlled by Sirpα in a time-dependent manner. Downregulation of macrophage S

SUBMITTER: Liu H 

PROVIDER: S-EPMC11662717 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature