Exploring the effects of probiotics on olanzapine-induced metabolic syndrome through the gut microbiota.

ABSTRACT:

Background

Maintaining gut microbial homeostasis is crucial for human health, as imbalances in the gut microbiota (GM) can lead to various diseases, including metabolic syndrome (MS), exacerbated by the use of antipsychotic medications such as olanzapine (OLZ). Understanding the role of the GM in OLZ-induced MS could lead to new therapeutic strategies. This study used metagenomic analysis to explore the impact of OLZ on the GM composition and examined how probiotics can mitigate its adverse effects in a rat model. Changes in weight, blood pressure, and lipid levels, which are key parameters defining MS, were assessed. Additionally, this study investigated serotonin, dopamine, and histopathological changes to explore their possible link with the microbiota-gut-brain axis (MGBA).

SUBMITTER: Mushraf S 

PROVIDER: S-EPMC11662719 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature