Different immunological patterns of Down syndrome patients with and without recurrent infections.

ABSTRACT:

Objective

Individuals with Down Syndrome (DS) exhibit a higher susceptibility to infections, suggesting potential immunological alterations within this population. Consequently, this study aims to assess the immune response profile in children with DS to identify potential immune dysfunctions associated with recurrent infections.

Methods

The authors conducted a retrospective analysis involving 49 DS patients, examining various epidemiological, clinical, cytogenetic, and laboratory variables. The study's sample comprised patients aged 2-20 years, with a predominance of males. These patients were categorized into two groups based on the presence or absence of recurrent infections, as indicated by the Jeffrey Modell Foundation alert signs.

Results

Immunoglobulin (Ig) A,

SUBMITTER: Martins KR 

PROVIDER: S-EPMC11662752 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature