Metabolic modelling uncovers the complex interplay between fungal probiotics, poultry microbiomes, and diet.

ABSTRACT:

Background

The search for alternatives to antibiotic growth promoters in poultry production has increased interest in probiotics. However, the complexity of the interactions between probiotics, gut microbiome, and the host hinders the development of effective probiotic interventions. This study explores metabolic modelling to examine the possibility of designing informed probiotic interventions within poultry production.

Results

Genomic metabolic models of fungi were generated and simulated in the context of poultry gut microbial communities. The modelling approach correlated with short-chain fatty acid production, particularly in the caecum. Introducing fungi to poultry microbiomes resulted in strain-specific and diet-dependent effects on the gut microbiome. The impact of f

SUBMITTER: Al-Nijir M 

PROVIDER: S-EPMC11662766 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature