Free-living monitoring of ALS progression in upper limbs using wearable accelerometers.

ABSTRACT:

Background

Wearable technology offers objective and remote quantification of disease progression in neurological diseases such as amyotrophic lateral sclerosis (ALS). Large population studies are needed to determine generalization and reproducibility of findings from pilot studies.

Methods

A large cohort of patients with ALS (N = 202) wore wearable accelerometers on their dominant and non-dominant wrists for a week every two to four weeks and self-entered the ALS Functional Rating Scale-Revised (ALSFRS-RSE) in similar time intervals. Wearable device data were processed to quantify digital biomarkers on four upper limb movements: flexion, extension, supination, and pronation using previously developed and validated open-source methodology. In this study, we determined the ass

SUBMITTER: Straczkiewicz M 

PROVIDER: S-EPMC11662782 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature