DEAD-box helicase family proteins: emerging targets in digestive system cancers and advances in targeted drug development.

ABSTRACT: Cancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of all newly diagnosed cancer cases worldwide. Despite significant improvements in early cancer screening, clinical diagnostics, and treatments in recent years, the overall prognosis of digestive system cancer patients remains poor. The DEAD-box helicase family, a crucial member of the RNA helicase family, participates in almost every aspect of RNA metabolism, including transcription, splicing, translation, and degradation, and plays a key role in the occurrence and progression of various cancers. This article aims to summarize and discuss the role and potential clinical applications of DE

SUBMITTER: Ma X 

PROVIDER: S-EPMC11662784 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature