Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study.

ABSTRACT:

Background

To investigate the associations of methylation, expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) with ankylosing spondylitis (AS) and find out genetically supported drug targets for AS.

Methods

The summary-data-based Mendelian randomization (SMR) and Bayesian co-localization analysis were used to assess the potential causality between AS and relevant genes. The GWAS data obtained from the International Genetics of Ankylosing Spondylitis Consortium (IGAS) were set as the discovery stage, and the FinnGen and UK Biobank databases were used to replicate the analysis as an external validation. We further integrated the multi-omics results to screen overlapped genes at different levels. The protein-protein interaction (PPI) network and enrichment a

SUBMITTER: Dai L 

PROVIDER: S-EPMC11662797 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature