Evaluation of leukocyte-platelet rich fibrin as an antibiotic slow-release biological device in the treatment of moderate periodontitis: a randomized controlled clinical trial.

ABSTRACT:

Background

Periodontitis is a chronic inflammatory disease caused by the accumulation of biofilm. Antimicrobials have been used as adjuncts to non-surgical periodontal therapy. However, systemic antibiotics often require large dosages to achieve suitable concentrations at the disease site. Leukocyte platelet-rich fibrin (L-PRF) is a promising bio-material, with antimicrobial, anti-inflammatory, and wound-healing enhancement effects. This study aimed to evaluate the efficacy of L-PRF as a locally sustained released device for metronidazole antimicrobial.

Methods

Twenty-four patients with eighty periodontal pockets had moderate periodontitis with attachment loss of 3-4 mm, and probing depth ≤ 5, which was equally divided into two groups: Group (I) underwent scaling and root pl

SUBMITTER: Omar YK 

PROVIDER: S-EPMC11662799 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature