Tracing the transmission of carbapenem-resistant Enterobacterales at the patient: ward environmental nexus.

ABSTRACT:

Introduction

Colonisation and infection with Carbapenem-resistant Enterobacterales (CRE) in healthcare settings poses significant risks, especially for vulnerable patients. Genomic analysis can be used to trace transmission routes, supporting antimicrobial stewardship and informing infection control strategies. Here we used genomic analysis to track the movement and transmission of CREs within clinical and environmental samples.

Methods

25 isolates were cultured from clinical patient samples or swabs, that tested positive for OXA-48-like variants using the NG-Test® CARBA-5 test and whole genome sequenced (WGS) using Oxford Nanopore Technologies (ONT). 158 swabs and 52 wastewater samples were collected from the ward environment. 60 isolates (matching clinical isolate genera;

SUBMITTER: Elton L 

PROVIDER: S-EPMC11662836 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature