Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B.

ABSTRACT:

Background

Breast cancer is the most prevalent cancer among women worldwide. Most breast cancer-related deaths result from metastasis and drug resistance. Novel therapies are imperative for targeting metastatic and drug-resistant breast cancer cells. Accumulating evidence suggests that dysregulated microRNAs (miRNAs) promote breast cancer progression, metastasis, and drug resistance. Compared with healthy breast tissue, miR-660-5p is notably overexpressed in breast cancer tumor tissues. However, the downstream effectors of miR-660-5p in breast cancer cells have not been fully elucidated. Our aim was to investigate the role of miR-660-5p in breast cancer cell proliferation, migration, invasion, and angiogenesis and to identify its potential targets.

Results

Our findings revea

SUBMITTER: Villarreal-Garcia V 

PROVIDER: S-EPMC11662842 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature