The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system.

ABSTRACT: Ubiquitination is a major post-translational regulatory mechanism that tunes numerous aspects of ubiquitinated target proteins, including localization, stability, and function. During differentiation and myelination, Oligodendrocytes (OLs) in the central nervous system and Schwann cells (SCs) in the peripheral nervous system undergo major cellular changes, including the tightly controlled production of large and accurate amounts of proteins and lipids. Such processes have been implied to depend on regulatory aspects of ubiquitination, with E3 ubiquitin ligases being generally involved in the selection of specific ubiquitination substrates by ligating ubiquitin to targets and granting target selectivity. In this study, we have used multiple transgenic mouse lines to investigate the function

SUBMITTER: Fimiani C 

PROVIDER: S-EPMC11662984 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature