Profound gastric mucosal changes and severe rebound acid hypersecretion after long-term Vonoprazan use: A case report.

ABSTRACT: Vonoprazan is a novel acid blocker with greater potency than proton pump inhibitors. A Japanese study reported no significant safety concerns over 5 years of Vonoprazan use; however, elevated serum gastrin and increased parietal cell and foveolar hyperplasia were observed, and long-term safety data beyond 5 years are limited. We report a case that used Vonoprazan for 6 years, complicated by significant gastric epithelial changes during treatment and acute duodenal mucosal lesions following its discontinuation. A 76-year-old, treated with proton pump inhibitors for over 10 years, was switched to Vonoprazan due to his worsening symptoms. After its use, hemorrhagic hyperplastic polyps became prominent. Given concerns about Vonoprazan's effect on the gastric epithelium, the medication was chan

SUBMITTER: Suda H 

PROVIDER: S-EPMC11662994 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature