Correlation of dynamic blood dose with clinical outcomes in radiotherapy for head-and-neck cancer.

ABSTRACT:

Background and purpose

Radiation-induced lymphopenia (RIL) during cancer radiotherapy is receiving growing attention due to its association with adverse clinical outcomes. Correlations between RIL and poorer locoregional control (LRC), distant-metastasis-free survival (DMFS), and overall survival (OS) have been demonstrated across multiple treatment sites. Estimates of radiation delivered to circulating blood or lymphocytes have been shown to be correlated with severe RIL. This study aims to evaluate whether blood dose estimates are equally correlated with patient outcomes directly.

Materials and methods

For 298 head-and-neck cancer patients, blood dose was estimated via the total body dose (D_body), a static blood dose model considering the mean dose to relevant o

SUBMITTER: Tattenberg S 

PROVIDER: S-EPMC11663108 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature