H3K9me3 loss and ERVs activation as hallmarks for osteoarthritis progression and knee joint aging.

ABSTRACT:

Objective

This study aims to link aberrant endogenous retroviruses (ERVs) activation and osteoarthritis (OA) progression by comparing the chromatin accessibility and transcriptomic landscapes of diseased or intact joint tissues of OA patients.

Method

We performed ERVs-centric analysis on published ATAC-seq and RNA-seq data from OA patients' cartilage tissues. Here, we compared the outer region of the lateral tibial plateau, representing intact cartilage, to the inner region of the medial tibial plateau, representing damaged cartilage. In addition, cartilage tissue sections from OA patients and post-traumatic OA mouse models were assayed for global H3K9me3 abundance through immunohistochemistry staining.

Results

Chromatin accessibility and transcription of ERVs, partic

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11663117 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature