CSF synaptic biomarkers and cognitive impairment in multiple sclerosis.

ABSTRACT:

Background

People with multiple sclerosis (PwMS) experience various degrees of cognitive impairment (CI). Synaptic dysfunction may contribute to CI in PwMS but cerebrospinal fluid (CSF) synaptic biomarkers are unexplored in MS.

Objective

To assess the role of CSF synaptosomal-associated protein 25 (SNAP-25), β-synuclein, neurogranin and neurofilament light chain protein (NfL) in patients with early relapsing MS with and without CI.

Methods

We measured CSF SNAP-25, β-synuclein, and neurogranin in 48 untreated PwMS and 50 controls with other neurological diseases (ONDs) and tested their associations with neuropsychological and MRI data.

Results

CSF synaptic protein levels did not discriminate between MS subjects and patients with ONDs, with only SNAP-25 values be

SUBMITTER: Barba L 

PROVIDER: S-EPMC11663154 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature