A comparative analysis of heme vs non-heme iron administration: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background and purpose

Bioavailability studies and observational evidence suggest that heme iron (HI) may have greater impact on iron status indicators compared with non-heme iron (NHI). This systematic review and meta-analysis aimed to review the current evidence on the effect of the administration of HI compared with NHI for improving iron status in non-hospitalized population groups.

Methods

We searched Pubmed, CENTRAL, Scopus, Web of Science, and LILACS from inception to July 2024. There was no language restriction or exclusion based on age or iron status. Only randomized controlled trials comparing HI with NHI were considered. A random-effects meta-analysis was performed to compare the effect of treatments for iron status indicators and total side effects (including gas

SUBMITTER: Gallo Ruelas M 

PROVIDER: S-EPMC11663168 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature