Construction and validation of immunogenic cell death-related molecular clusters, signature, and immune landscape in pancreatic cancer.

ABSTRACT: Pancreatic cancer (PC) is a malignancy of the gastrointestinal tract that is characterized by a poor prognosis. This study investigates the roles of immunogenic cell death (ICD) genes in the prognosis and progression of PC. Expression data for PC patients were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, while ICD genes were sourced from published literature. We explored the expression patterns and identified two distinct clusters based on ICD genes. Kaplan-Meier analysis, differential expression analysis, tumor mutational burden analysis, and immune cell infiltration analysis were performed on these clusters. An ICD gene-based risk model was developed, categorizing samples from the TCGA and GEO datasets into low- and high-risk groups. Additional

SUBMITTER: Hu CY 

PROVIDER: S-EPMC11663176 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature