Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance.

ABSTRACT:

Aims/hypothesis

Metabolic disorders associated with abdominal obesity, dyslipidaemia, arterial hypertension and hyperglycaemia are risk factors for the development of insulin resistance. Extracellular vesicles (EVs) may play an important role in the regulation of metabolic signalling pathways in insulin resistance and associated complications.

Methods

Circulating large EVs (lEVs) and small EVs (sEVs) from individuals with (IR group) and without insulin resistance (n-IR group) were isolated and characterised. lEVs and sEVs were administered by i.v. injection to mice and systemic, adipose tissue and liver insulin signalling were analysed. The role of phosphatases was analysed in target tissues and cells.

Results

Injection of lEVs and sEVs from IR participants impaired s

SUBMITTER: Ali S 

PROVIDER: S-EPMC11663195 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature