Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization.

ABSTRACT:

Background

Previous clinical studies have suggested an increased risk of tumor development in patients with pulmonary arterial hypertension (PAH). However, it remains unclear whether there is a causal relationship between PAH and tumor occurrence. This study investigates the causal link between PAH and cancer from a genetic perspective using Mendelian randomization (MR).

Method

Genome-wide association study (GWAS) summary data for PAH and various common cancer types were obtained from the GWAS Catalog. Single nucleotide polymorphisms (SNPs) significantly associated with PAH at the genome-wide significance threshold (P < 1 × 10^-6) were selected as instrumental variables (IVs). Inverse-variance weighted (IVW) was used as the primary method for MR analysis, with sens

SUBMITTER: Fu Y 

PROVIDER: S-EPMC11663201 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature