Impact of gout on colorectal cancer and its survival: a two-sample Mendelian randomization study.

ABSTRACT:

Background

The relationship between gout and colorectal cancer (CRC) remains unclear, emphasizing the need for additional research to clarify the potential cumulative effect of gout on CRC development.

Methods

Leveraging a single nucleotide polymorphism-based genome-wide association study, the potential causal correlation between gout and CRC was initially analyzed using Mendelian randomization (MR). Subsequently, our analysis was expanded to include an assessment of patient survival, with the aim of evaluating the potential causal correlation between gout and CRC and the impact of gout on CRC survival outcomes.

Results

According to MR findings, a substantial relationship was observed between gout and the incidence of CRC when CRC was used as the outcome (OR = 0.954,

SUBMITTER: Wei LQ 

PROVIDER: S-EPMC11663203 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature