Chelation of [¹¹¹In]In³⁺ with the dual-size-selective macrocycles py-macrodipa and py₂-macrodipa.

ABSTRACT: Indium-111 (¹¹¹In) is a diagnostic radiometal that is important in nuclear medicine for single-photon emission computed tomography (SPECT). In order to apply this radiometal, it needs to be stably chelated and conjugated to a targeting vector that delivers it to diseased tissue. Identifying effective chelators that are capable of binding and retaining [¹¹¹In]In³⁺in vivo is an important research area. In this study, two 18-membered macrocyclic chelators, py-macrodipa and py₂-macrodipa, were investigated for their ability to form stable coordination complexes with In³⁺ and to be effectively radiolabeled with [¹¹¹In]In³⁺. The In³⁺ complexes of these two chelators were characterized by NMR spectrosco

SUBMITTER: Lee KK 

PROVIDER: S-EPMC11663299 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature