Metagenomic insights into the resistome, mobilome, and virulome of dogs with diverse lifestyles.

ABSTRACT:

Background

Dogs-whether pets, rural, or stray-exhibit distinct living styles that influence their fecal microbiota and resistomes, yet these dynamics remain underexplored. This study aimed to analyze and compare the fecal microbiota and resistomes of three groups of dogs (37 pets, 20 rural, and 25 stray dogs) in Shanghai, China.

Results

Metagenomic analysis revealed substantial differences in fecal microbial composition and metabolic activities among the dog groups. Pet dogs displayed the lowest microbial diversity. Using Shapley Additive Explanations (SHAP), an interpretable machine learning approach, Ligilactobacillus emerged as the most diverse genus, with significantly higher SHAP values in stray dogs, suggesting enhanced adaptability to more variable and less controlled

SUBMITTER: Zhou N 

PROVIDER: S-EPMC11663309 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature