Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis.

ABSTRACT:

Background

We aim to explore the impact of excessive glutathione (GSH) intake on chemotherapy sensitivity in breast cancer.

Methods

Clinicopathological data were collected from 460 breast cancer patients who underwent adjuvant chemotherapy from January 2016 to December 2019 from Zhengzhou University People's Hospital. The clinicopathological characteristics following GSH treatment were collected and compared with those in Non-GSH group after 1:2 propensity score matching (PSM). Intracellular GSH levels and the expression of antioxidant enzymes (NRF2, GPX4 and SOD1) were evaluated in tumor tissues in 51 patients receiving neoadjuvant chemotherapy.

Results

The recurrence rate after adjuvant chemotherapy was significantly higher in the GSH group (n = 28, 31.8%) than that

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11663319 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature