Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth.

ABSTRACT: Glioblastoma tumors are the most common and aggressive adult central nervous system malignancy. Nearly all patients experience disease progression, which significantly contributes to disease mortality. Recently, it has been suggested that recurrent tumors may be characterized by a ferroptosis-prone phenotype with a significant decrease in glutathione peroxidase 4 (GPx4) expression. This led to the hypothesis that GPx4 expression negatively influences GBM cell growth. This study utilizes a doxycycline inducible GPx4 overexpression model to test this hypothesis. Consistently, the overexpression of GPx4 significantly impairs cell growth and colony formation while also causing an accumulation of cells in G1/G0 phase of the cell cycle. From a biophysical perspective, GPx4 overexpressing cells h

SUBMITTER: Teferi N 

PROVIDER: S-EPMC11663334 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature