Screening and identification of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica.

ABSTRACT:

Background

The overuse of antibiotics has led to lethal multi-antibiotic-resistant microorganisms around the globe, with restricted availability of novel antibiotics. Compared to conventional antibiotics, evolutionarily originated antimicrobial peptides (AMPs) are promising alternatives to address these issues. The gut microbiome of Blattella germanica represents a previously untapped resource of naturally evolving AMPs for developing antimicrobial agents.

Results

Using the in-house designed tool "AMPidentifier," AMP candidates were mined from the gut microbiome of B. germanica, and their activities were validated both in vitro and in vivo. Among filtered candidates, AMP1, derived from the symbiotic microorganism Blattabacterium cuenoti, demonstrated broad-spectrum antibacte

SUBMITTER: Chen S 

PROVIDER: S-EPMC11663339 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature