Effects of orally administered clioquinol on the fecal microbiome of horses.

ABSTRACT:

Background

Whereas restoration of fecal consistency after treatment with clioquinol for chronic diarrhea and free fecal water syndrome has been attributed to its antiprotozoal properties, actions of clioquinol on the colonic bacterial microbiota have not been investigated.

Objectives

Characterize the dynamics of fecal microbial diversity before, during, and after PO administration of clioquinol to healthy horses.

Study design

Experimental prospective cohort study using a single horse group.

Methods

Eight healthy adult horses received PO clioquinol (10 g, daily) for 7 days. Feces were obtained daily for 7 days before, during, and after conclusion of treatment, and again 3 months later. Libraries of 16S rRNA V4 region amplicons generated from fecal DNA were seque

SUBMITTER: Smith MZ 

PROVIDER: S-EPMC11663420 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature