The association between cigarette smoking and dementia with Lewy bodies.

ABSTRACT:

Introduction

Cigarette smoking is associated with a reduced risk of Parkinson's disease (PD). As dementia with Lewy bodies (DLB) and PD share core neuropathologic features, we set out to examine the relationship between smoking and DLB.

Methods

Diagnosis at baseline visit and smoking history of participants ≥50 years old in the National Alzheimer's Coordinating Center (NACC) cohort were evaluated in this cross-sectional study. Odds of diagnosis of cognitive impairment due to DLB, PD, vascular dementia (VD), or Alzheimer's disease (AD) compared to normal cognition based on smoking status and duration were determined using logistic regression.

Results

37,478 participants were included (mean age 72 years (SD 9), 57 % female). The odds of DLB were reduced in all smoking s

SUBMITTER: Goodheart AE 

PROVIDER: S-EPMC11663461 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature