Novel T-cell subsets as non-invasive biomarkers of vascular damage along the predialysis stages of chronic kidney disease.

ABSTRACT:

Introduction

Cardiovascular disease is the major cause of premature death in chronic kidney disease (CKD) and vascular damage is often detected belatedly, usually evaluated by expensive and invasive techniques. CKD involves specific risk factors that lead to vascular calcification and atherosclerosis, where inflammation plays a critical role. However, there are few inflammation-related markers to predict vascular damage in CKD. This study aimed to investigate immune populations in pre-dialysis patients to (i) identify subset alterations, (ii) assess longitudinal changes, and (iii) evaluate their applicability as biomarkers of subclinical vascular indices.

Methods

43 pre-dialysis CKD patients in stages CKD-2 to CKD-5 and 38 controls were recruited at baseline and after 18-mon

SUBMITTER: Martin-Virgala J 

PROVIDER: S-EPMC11663642 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature