Influence of renal function on blood pressure control and outcome in thrombolyzed patients after acute ischemic stroke: <i>post-hoc</i> analysis of the ENCHANTED trial.

ABSTRACT:

Background

The effect of renal impairment in patients who receive intravenous thrombolysis for acute ischemic stroke (AIS) is unclear. We aimed to determine the associations of renal impairment and clinical outcomes and any modification of the effect of intensive versus guideline-recommended blood pressure (BP) control in the BP arm of the International Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).

Methods

We conducted a post-hoc analysis of the ENCHANTED BP arm, which involved 2,196 thrombolyzed AIS patients. Logistic regression models were used to define the association between eGFR and clinical outcomes of death, death or major disability [modified Rankin scale (mRS) scores 3-6], and major disability (mRS 3-5) at 90 days.

Results

SUBMITTER: Ren X 

PROVIDER: S-EPMC11663659 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature