Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults.

ABSTRACT: Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster vaccination, they produced fewer spike-specific circulating follicular helper T cells-1 than younger adults. Similarly, the cytotoxic CD8⁺ T-cell response remained diminished with reduced PD-1 expression even after booster vaccination compared with that in younger adults, suggesting impaired memory T-cell activation in older adults. In contrast, although B-cell responses in older adults were weaker than those in younger adults in the primary response, the responses were significantly enhanced upon booster vaccination, reaching levels comparable w

SUBMITTER: Kometani K 

PROVIDER: S-EPMC11663736 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature