Association between phenotypic age and mortality risk in individuals with obesity: a retrospective cohort study.

ABSTRACT:

Objective

This study investigates the association between phenotypic age acceleration (PAA) and all-cause and cause-specific mortality in obese individuals.

Methods

Data were drawn from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018, including 9,925 obese adults (BMI ≥ 30 kg/m²). PAA, defined as phenotypic age exceeding chronological age, was assessed using clinical biomarkers. Kaplan-Meier survival analysis and Cox proportional hazards models were used to assess the relationship between PAA and all-cause, cardiovascular, and cancer mortality, adjusting for covariates such as age, gender, race, lifestyle, and health status. Subgroup and sensitivity analyses were performed to ensure the robustness of the findings.

Results

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11663737 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature