T-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions.

ABSTRACT:

Introduction

T-cadherin, a non-canonical member of the cadherin superfamily, was initially identified for its involvement in homophilic recognition within the nervous and vascular systems. Apart from its adhesive function, T-cadherin acts as a receptor for two ligands: LDL, contributing to atherogenic processes, and HMW adiponectin, a hormone with well-known cardiovascular protective properties. However, the precise role of T-cadherin in adipose tissue remains elusive. Previously, we generated Cdh13^∆Exon3 mice lacking exon 3 in the Cdh13 gene, which encodes the T-cadherin protein, and characterized their phenotype.

Methods

Using wild-type (WT) and T-cadherin-deficient mice (Cdh13ΔExon3), we isolated and cultured mesenchymal stem cells to explore the role of T-cadh

SUBMITTER: Sysoeva V 

PROVIDER: S-EPMC11663858 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature