The impact of zinc pre-exposure on ciprofloxacin resistance development in E. coli.

ABSTRACT:

Introduction

Antimicrobial resistance (AMR) is a global health crisis that is predicted to worsen in the coming years. While improper antibiotic usage is an established driver, less is known about the impact of other endogenous and exogeneous environmental factors, such as metals, on AMR. One metal of interest is zinc as it is often used as a supplement for diarrhea treatment prior to antibiotics.

Materials and methods

Here, we probed the impact of zinc on ciprofloxacin resistance in E. coli via altering zinc exposure time and order. We found that the order of exposure to zinc impacted resistance development. These impacted samples then underwent whole genome and RNA sequencing analysis.

Results

Zinc pre-exposure led to a subsequent acceleration of ciprofloxaci

SUBMITTER: Suprenant MP 

PROVIDER: S-EPMC11663908 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature