Gross anatomical features of the insular cortex in affective disorders.

ABSTRACT:

Introduction

The number of insular gyri is elevated in patients with schizophrenia. Thus, it has potential as a marker of early neurodevelopmental abnormalities. However, currently it remains unclear whether patients with other neuropsychiatric disorders, such as affective disorders, also have this gross brain anatomical feature.

Materials and methods

The macroscopic features of the insular cortex in 26 patients with bipolar disorder (BD), 56 with major depressive disorder (MDD), and control subjects for each clinical group (24 for BD and 33 for MDD) were assessed using magnetic resonance imaging.

Results

The number of short insular gyri was higher in BD patients than in matched controls bilaterally with well-developed accessory and middle short gyri. Furthermore, the

SUBMITTER: Takahashi T 

PROVIDER: S-EPMC11663932 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature