Assessment of azithromycin-induced toxicity in <i>Caenorhabditis elegans</i>: Effects on morphology, behavior, and lipid metabolism.

ABSTRACT: Antibiotics are indispensable in modern healthcare, playing a critical role in mitigating bacterial infections. Azithromycin is used to fight upper respiratory tract infections, however has potential toxic effects that remain inadequately understood. In our present study, azithromycin exposure to Caenorhabditis elegans led to significant physiological and behavioral change, with pronounced effects observed at the studied concentration. The study employs an N2 wild-type strain to examine key physiological and behavioral parameters within the worm. C.elegans were exposed to two concentrations of azithromycin (0.0038 and 0.00038 mg/ml) from the embryonic stage to the L4 stage for 48 hours. The study assessed key endpoints including body length, thrashing behavior, brood size, em

SUBMITTER: Kalugendo E 

PROVIDER: S-EPMC11664063 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature