When to stop immunotherapy for advanced melanoma: the emulated target trials.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have demonstrated their efficacy with a 7.5-year overall survival (OS) close to 50% for advanced stages. The design of clinical trials provides for treatment until progression or toxicity, or for a maximum duration of two years. Prolonged follow-up of responders after treatment cessation shows sustained response and a low risk of relapse in the months following cessation. To date, the optimal duration of anti-PD-1 therapy for metastatic melanoma remains unestablished. The objective of this work was to evaluate the optimal duration of ICI administration.

Methods

We emulated target trials using the cloning, weighting and censoring approach. Each emulation trial aimed to compare the effect of discontinuing versus continuing ICIs at

SUBMITTER: Amiot M 

PROVIDER: S-EPMC11664069 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature