The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics.

ABSTRACT: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are neurodegenerative disorders caused by the accumulation of misfolded conformers (PrP^Sc) of the cellular prion protein (PrP^C). During the pathogenesis, the PrP^Sc seeds disseminate in the central nervous system and convert PrP^C leading to the formation of insoluble assemblies. As for conventional infectious diseases, variations in the clinical manifestation define a specific prion strain which correspond to different PrP^Sc structures. In this work, we implemented the recent developments on PrP^Sc structural diversity and tissue response to prion replication into a stochastic reaction-diffusion model using an application of the Gillespie algorithm. We showed

SUBMITTER: Fornara B 

PROVIDER: S-EPMC11664133 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature