Baicalin promotes β-1,3-glucan exposure in Candida albicans and enhances macrophage response.

ABSTRACT: Among the diverse fungal opportunistic pathogens, Candida albicans garners significant attention due to its wide range of infections and high frequency of occurrence. The emergence of resistance and the limited number of antifungals drives the need to develop novel antifungal drugs. Although the natural product baicalin has been shown to trigger apoptosis in C. albicans in previous experiments, its influence on cell wall (CW) structure along with immune recognition remains elusive. In this work, baicalin showed a significant killing effect against C. albicans SC5314. Moreover, CW destruction, characterized by β-1,3-glucan unmasking and chitin deposition, was observed as a consequence of the treatment with baicalin. The RNA sequencing analysis revealed that treatment wi

SUBMITTER: Pan Y 

PROVIDER: S-EPMC11664218 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature