Adaptable Manufacturing and Biofabrication of Milliscale Organ Chips With Perfusable Vascular Beds.

ABSTRACT: Microphysiological systems (MPS) containing perfusable vascular beds unlock the ability to model tissue-scale elements of vascular physiology and disease in vitro. Access to inexpensive stereolithography (SLA) 3D printers now enables benchtop fabrication of polydimethylsiloxane (PDMS) organ chips, eliminating the need for cleanroom access and microfabrication expertise, and can facilitate broader adoption of MPS approaches in preclinical research. Rapid prototyping of organ chip mold designs accelerates the processes of design, testing, and iteration, but geometric distortion and surface roughness of SLA resin prints can impede the development of standardizable manufacturing workflows. This study reports postprocessing procedures for manufacturing SLA-printed molds that produce fully cured

SUBMITTER: Byrne CE 

PROVIDER: S-EPMC11664230 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature