Systematic characterization of the barrier function of diverse <i>ex vivo</i> models of damaged human skin.

ABSTRACT:

Background

The skin barrier plays a crucial role in protecting our body against external agents. Disruption of this barrier's function leads to increased susceptibility to infections and dermatological diseases. Damaged skin can be due to the use of detergents, sunburn or excessive scratching. In the context of the COVID-19 pandemic the recommended hygiene measures to prevent the spread of SARS-CoV-2, such as wearing masks, frequent handwashing, and the use of sanitizers, can also potentially alter the skin barrier.

Objectives

The purpose of the study was to characterize the barrier function of ex vivo models of damaged human skin.

Methods

Skin barrier damage was induced through different chemical and mechanical treatments, representative of the potential facto

SUBMITTER: Barthe M 

PROVIDER: S-EPMC11664247 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature