Bakuchiol from Cullen corylifolium and its efficacy on apoptosis and autophagy in HepG2 cells.

ABSTRACT: Bakuchiol (4), a component of Cullen corylifolium, has been reported to have estrogenic, antimicrobial, and anti-inflammatory activities. Nonetheless, its anticancer mechanisms and effectiveness against hepatocellular carcinoma remain unexplored. This study sought to elucidate the mechanism of apoptosis, autophagy, and cell cycle arrest caused by bakuchiol (4) and three flavonoids (1-3) with similar structures to compound 4 in hepatocellular carcinoma. Among the evaluated components (1-4), bakuchiol (4) exhibited a significant potential to induce apoptosis in HepG2 cells. This compound facilitates apoptotic processes by engaging both intrinsic and extrinsic signaling cascades, as evidenced by the enhanced ratios of Bax to Bcl-2

SUBMITTER: Lee YG 

PROVIDER: S-EPMC11664279 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature