Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population-based study.

ABSTRACT:

Objective

Previous research may have underestimated the relationship between overweight/obesity and colorectal cancer (CRC) risk by overlooking important potential sources of bias.

Methods

We used data from a large, population-based case-control study encompassing 7098 CRC cases and 5757 age- and sex-matched controls with comprehensive information on risk factors, including self-reported body weight. Multivariate logistic regression was used to assess the associations of BMI with CRC risk before and after considering prediagnostic weight loss, history of lower gastrointestinal endoscopy, and potentially increased CRC risk beneath the overweight threshold (BMI 25 kg/m²). Subsequently, population attributable fractions were calculated.

Results

In the standard

SUBMITTER: Mandic M 

PROVIDER: S-EPMC11664302 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature