Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity.

ABSTRACT:

Objective

This study investigated how obesity, BMI ≥ 30 kg/m², abdominal adiposity, and systemic inflammation relate to neuroinflammation using diffusion basis spectrum imaging.

Methods

We analyzed data from 98 cognitively normal midlife participants (mean age: 49.4 [SD 6.2] years; 34 males [34.7%]; 56 with obesity [57.1%]). Participants underwent brain and abdominal magnetic resonance imaging (MRI), blood tests, and amyloid positron emission tomography (PET) imaging. Abdominal visceral and subcutaneous adipose tissue (VAT and SAT, respectively) was segmented, and Centiloids were calculated. Diffusion basis spectrum imaging parameter maps were created using an in-house script, and tract-based spatial statistics assessed white matter differences in high versus low

SUBMITTER: Dolatshahi M 

PROVIDER: S-EPMC11664304 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature