DNA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI.

ABSTRACT:

Objective

We investigated whether prepregnancy BMI (prePregBMI) in women with obesity was associated with differential DNA methylation (DNAm) in cord blood (CB) and whether DNAm may mediate the association of prePregBMI and early childhood BMI z score (BMIz).

Methods

From the Treatment of Obese Pregnant Women (TOP) study, 232 mother-child pairs were included. We conducted an epigenome-wide association study on prePregBMI and CB DNAm (450k array), followed by causal mediation analyses to test whether DNAm may mediate effects of prePregBMI on  BMIz at age 36 months (BMIz36).

Results

DNAm at 5345 CpG sites annotated to 2842 genes, which were overrepresented in biological processes linked to carbohydrate metabolism and plasma lipoprotein particle clearance, was associated

SUBMITTER: Maguolo A 

PROVIDER: S-EPMC11664306 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature