Beyond BRAF^V600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children.

ABSTRACT:

Background

Langerhans cell histiocytosis (LCH) is the most prevalent histiocytic disorder in pediatric populations, with a highly heterogeneous clinical presentation. Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAF^V600E mutation, has not been sufficiently studied.

Methods

This study presented data on 33 pediatric LCH patients treated at our center who exhibited various molecular alterations other than the BRAF^V600E mutation. Additionally, we comprehensively reviewed pediatric LCH cases with non-BRAF^V600E molecular alterations reported from January 2010 to August 2024.

Results

A total of 309 pediatric LCH patients with molecular alterations beyond BRAF^V600E w

SUBMITTER: Tang X 

PROVIDER: S-EPMC11664316 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature