Intermolecular Asymmetric Arylative Dearomatization of 1-Naphthols.

ABSTRACT: Arylative dearomatization forms quaternary stereocenters in cyclic systems with the concomitant introduction of an aromatic ring. Pd-catalyzed arylative dearomatization, which uses conditions analogous to cross-coupling, has emerged as a powerful method in an intramolecular context. But translating this from intramolecular cyclizations to an intermolecular process has proven extremely challenging: examples are scarce, and those that exist have not been rendered enantioselective, despite the potential for broad application in medicinal chemistry and natural product synthesis. We describe a strategy that utilizes attractive interactions between the ligand and substrate to overcome this challenge and promote intermolecular, highly enantioselective arylative dearomatization of naphthols using

SUBMITTER: Kadarauch M 

PROVIDER: S-EPMC11664591 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature