Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus.

ABSTRACT:

Background

This study aimed to explore the association between admission HbA1c and the risk of 1-year vascular outcomes stratified by age group in patients with acute ischemic stroke (AIS) and diabetes mellitus (DM).

Methods

This study analyzed prospective multicenter data from patients with AIS and DM. Admission HbA1C were categorized as:≤6.0%, 6.1%-7.0%, 7.1%-8.0%, and >8.0%. Age was analyzed in categories:≤55 years, 56-65 years, 66-75 years, 76-85 years, and >85 years. The primary outcome was 1-year composite of stroke, MI, and all-cause mortality. The modifying effect of age on the relationships between HbA1c and 1-year primary outcome was explored by Cox proportional hazards model.

Results

A total of 16,077 patients (age 69.0 ± 12.4 years; 59.4% males) were analy

SUBMITTER: Kim JT 

PROVIDER: S-EPMC11664728 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature