Prostruc: an open-source tool for 3D structure prediction using homology modeling.

ABSTRACT:

Introduction

Homology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. However, existing tools often require significant expertise and computational resources, presenting a barrier for many researchers.

Methods

Prostruc is a Python-based homology modeling tool designed to simplify protein structure prediction through an intuitive, automated pipeline. Integrating Biopython for sequence alignment, BLAST for template identification, and ProMod3 for structure generation, Prostruc streamlines complex workflows into a user-friendly interface.

SUBMITTER: Pawar SV 

PROVIDER: S-EPMC11664737 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature