Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice.

ABSTRACT: Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD-associated metabolic comorbidity, hyperlipidemia, in mdx mice by inactivating the apolipoprotein E gene (mdx-ApoE) we previously reported severe myofiber damage exacerbation via histology with large fibro-fatty infiltrates and phenotype humanization with ambulation dysfunction when fed a cholesterol- and triglyceride-rich Western diet (mdx-ApoE^W). Herein, we performed comparative lipidomic and metabolomic analyses of muscle, liver and serum samples from mdx and mdx-ApoE^W mice using solution and high-resolution-magic angle spinning (HR-MAS) ¹H-NMR spectroscopy. Compared to mdx and regular chow-fed

SUBMITTER: Khattri RB 

PROVIDER: S-EPMC11664822 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature