Contextualised Processing of Stimuli Modulates Auditory Mismatch Responses in the Rat.

ABSTRACT: Mismatch negativity (MMN), an auditory prediction error signal, is an enhanced response to unexpected (deviant) stimuli compared to expected (standard) stimuli. There is strong interest in MMN due to reliable findings of reduced MMN in schizophrenia. To interpret reduced MMN in schizophrenia, an enhanced understanding of the factors that influence MMN amplitude could lead to a better understanding of neural mechanisms underpinning the reduction. While several laboratories have observed mismatch responses (MMRs) in rodents, this study assesses how MMR is altered in more complex auditory sequences in rats. Prediction-errors are elicited in relation to "predictive" internal models of regularities. These internal models are updated dynamically when a regularity changes, but human MMN exhibits

SUBMITTER: Jalewa J 

PROVIDER: S-EPMC11664890 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature